Lamdhade SJ, Thussu A, Al Benwan KO and Alroughani R
Objectives: To report a case of Listeria monocytogen meningitis; a rare complication during Infliximab therapy for ulcerative colitis during early pregnancy. Case presentation and intervention: A 28 year old woman was treated with prior immunosuppression and recent infliximab for ulcerative colitis. Pregnancy was confirmed at second infliximab infusion. Five days after the third dose, she developed signs of acute meningitis with subsequent VI cranial neuropathy. Cerebrospinal fluid Gram-stain suspected listeria monocytogen organisms, which was confirmed by blood and cerebrospinal fluid cultures. Meningitis was successfully treated with Ampicillin and Gentamycin. Spontaneous Intrauterine death of fetus occurred at 15 weeks gestation. Conclusions: This case highlights the importance of high index of suspicion of opportunistic infections such as Listeria meningitis with the use of infliximab.