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Forschungsartikel

Implications of Androgen Receptor Hyperstimulation by the FKBP51 L119P Mutation: No Evidence for Early Emergence of L119P in Prostate Cancer

Bryan K. Ward*, Carmel Cluning, Ajanthy Arulpragasam, Jacqueline M. Bentel, David C. Chandler, Ronald J. Cohen, Gunnar Fischer, Michael R.Epis, Peter J. Leedman, Wayne D. Tilley Australian Prostate Cancer BioResource and Thomas Ratajczak

Objective: The immunophilin cochaperones, FKBP51 and FKBP52, have a modulating effect on steroid hormone receptors including the androgen receptor (AR). The dif..Mehr sehen»

Fallbericht

Response to Insulin Glargine 100 U/Ml Treatment in Newly Identified Type 2 Diabetes Subgroups: Post Hoc Pooled Analysis of Patients in Nine Randomised Clinical Trials Who Have Never Taken Insulin

Wolfang Lagraf

Aims: To examine the outcomes of the treatment with insulin glargine 100 U/mL (IGlar-100) in newly identified subgroups of type 2 diabetes mellitus (T2DM).

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Kleiner Rückblick

Association of Distal Deletion of the Short arm of Chromosome 9 with 46,XY Disorder of Sex Development and Gonadoblastoma

Del Rey G, Venara M, Papendieck P, Gru?eiro L, Tangari A, Boywitt A, Casali B, Laudicina A

Deletion of the short arm of chromosome 9 is associated with two distinct clinical prototypes. Small telomeric distal 9p deletions have been reported in patients 46,XY with gona..Mehr sehen»

Rezensionsartikel

A Comprehensive Evaluation of Solid Tumor Analysis in the Clinical Space

Kevin Kelly, Aleksandra Ras, Samantha Helm, Vanessa Spotlow and Honey V Reddi

Solid tumors remain a major health concern with approximately 14 million new cases and 8.2 million cancerrelated deaths per year. Currently multimodality treatment regimens are ..Mehr sehen»

Rezensionsartikel

Diabetes and Bone

Peter Vestergaard

Diabetes – both type 1 (T1D) and type 2 (T2D) has profound effects on the skeleton. Bone turnover is reduced, i.e. bone biopsies show a reduced bone formation with reduced..Mehr sehen»

Forschungsartikel

Isotopic Differentiation Protocol, a Selective Extraction of C- and N-Terminal Ions in ESI-Ms/Ms De Novo Peptide Sequencing

Mako Fujii, Hiroshi Chiba, Noriko Tamayama, Saki Kanamaru and Masaru Hashimoto

Simple and selective extraction method of C- and N-terminal ions in ESI-MS/MS analyses, named isotopic differentiation protocol (IDP), was developed. It takes a..Mehr sehen»