MD Varmora, CB Dumatar, CK Desai
Introduction: Isotretinoin is most effective in treatment of severe nodulocystic acne and in the prevention of acne scarring. However, it may provoke Adverse Drug Reaction (ADR) in mucocutaneous and hepatic tissues and lead to alterations in lipid profile. Objective: To evaluate effect of isotretinoin on liver enzymes and lipid profile and other ADRs in patients of acne vulgaris. Methods: This was an observational, prospective, continuous study carried out in outdoor patients of skin department at a tertiary care teaching hospital. Data were analyzed for demographic details, clinical management and laboratory investigations (liver enzymes and lipid profile at base line, after 1 month and 3 months of treatment). Other ADRs were also recorded. Results: Total 29 patients of severe acne (grade III & IV) treated with isotretinoin 20mg/day were enrolled. No significant elevation was observed in AST, ALT and serum triglyceride level. Dryness of skin and lips were reported in 62% of users, followed by skin exfoliation, chelitis and nausea. Statistical test: Data were analysed using repeated measures ANOVA test. Conclusion: Isotretinoin does not alter lipid profile and liver enzymes. Other ADRs were mild and the drug was well tolerated.